FcRn: an IgG Receptor on Phagocytes with a Novel Role in Phagocytosis Running title: Phagocyte FcRn
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FcRn: an IgG Receptor on Phagocytes with a Novel Role in Phagocytosis Running title: Phagocyte FcRn Gestur Vidarsson, Annette M. Stemerding, Nigel M. Stapleton, Suzanne E. Spliethoff, Hans Janssen, Frank E.M. Rebers, Masja de Haas, and Jan G.J. van de Winkel 1) Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, The Netherlands, 2) Laboratory of Vaccine Research, The Netherlands Vaccine Institute 3) Dept. Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands, 4) Eijkman-Winkler Institute, University Medical Center Utrecht, The Netherlands, 5) Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands, 6) Genmab, Utrecht, The Netherlands
منابع مشابه
FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis.
Here, we report that the MHC class I-related neonatal Fc receptor (FcRn) is expressed within azurophilic and specific granules of neutrophils and relocates to phagolysosomes on phagocytosis of IgG-opsonized bacteria. We found FcRn to enhance phagocytosis in a pH-dependent manner which was independent of IgG recycling. IgG-opsonized bacteria were inefficiently phagocytosed by neutrophils from be...
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تاریخ انتشار 2006